Moore studied drawing, painting, and printmaking at the University of Louisville while working on Battle Pope, though he left his studies before obtaining his degree to pursue his career as a comic book illustrator, when he was asked to produce work for the Mattel-licensed Masters of the Universe property. Shortly afterward, with Robert Kirkman, they launched Brit and The Walking Dead at Image Comics. Since he has worked on Fear Agent, The Exterminators and most recent Ghost Rider with Jason Aaron.

Moore was nominated for two Eisner Awards for his work on The Walking Dead, (2004: Best New Series, and 2005: Best Cover Artist).

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